The role of indigenous knowledge in the fight against HIV/AIDS in Africa is beginning to gain recognition within scientific circles. However, the usefulness of traditional medicine for the treatment of HIV/AIDS is still controversial. A careful analysis of traditional medicine in Bamendankwe of the Northwest province of Cameroon reveals that some of the traditional doctors are capable of applying both psychological and real methods to combat the pandemic, but also to improve on the lifespan of those suffering from HIV/AIDS. Recognition of the potential contribution of traditional (both psychological and real treatment methods) healing practices could permit a more objective scientific assessment of the effectiveness of many indigenous knowledge systems, not only in Cameroon but the world at large. This paper examines the role of traditional healing practices vis-à-vis the present state of HIV/AIDS in Bamendankwe. Extracts to indicate patient’s experiences with traditional healers on one hand and traditional healers with patients on the other, over a five year period are included.